Alice Gottlieb, MD, PhD, has played an intrinsic role in the evolution of the treatment of psoriasis and psoriatic arthritis. Her research, using targeted immunobiologics as pathogenic probes, provided new understanding of the pathogenesis of psoriasis and provided the foundation for biologic drug development in psoriasis and psoriatic arthritis. Throughout her career, she has taught dermatologists how to diagnose and manage psoriatic arthritis.