Joel M. Gelfand, MD, MSCE, professor of dermatology and epidemiology, University of Pennsylvania Perelman School of Medicine, has researched and published extensively on the epidemiology of psoriasis and psoriatic arthritis, the impact of psoriasis on health-related quality of life, and the risk of various comorbidities such as obesity, diabetes, hyperlipidemia, lymphoma, renal disease, dementia, major cardiovascular events, and mortality associated with psoriasis. Dr.

Scientists believe that certain synovial cells contribute to inflammation by activating synovial fibroblasts in people who suffer from rheumatoid arthritis (RA). They believe that having a deeper understanding of the mechanisms of inflammation in the disease is important for designing new therapies for RA.

Patients with inflammatory bowel disease are more likely to see dramatic shifts in the make-up of the community of microbes in their gut than healthy people, according to the results of a study published online Feb. 13 in Nature Microbiology.

The prevalence of diabetes is higher in patients with psoriatic arthritis (PsA), with greater PsA activity correlating with a higher risk of developing the disease, according to recent research published in The Journal of Rheumatology.


A new study identified a bacterial connection between Crohn disease and peripheral spondyloarthritis (SpA) in the form of Escherichia coli (E coli).

Previous research has suggested connections between Crohn disease and SpA, but the mechanisms behind the gut microbiome’s influence on this condition are less well understood.


High levels of a type of E. coli found in patients with Crohn’s disease triggers inflammation associated with spondyloarthritis, according to a study published in Science Translational Medicine.

Individuals who have psoriasis or psoriatic arthritis are at a significantly higher risk of also suffering bone fractures, particularly in their hip and vertebrae, according to a new study published in the Annals of the Rheumatic Diseases.


New findings reveal an association between smoking and the concurrent presence of multiple rheumatoid arthritis (RA)-related autoantibodies, rather than only anti-citrullinated protein antibodies (ACPA).


Alice Gottlieb, MD, PhD, has played an intrinsic role in the evolution of the treatment of psoriasis and psoriatic arthritis. Her research, using targeted immunobiologics as pathogenic probes, provided new understanding of the pathogenesis of psoriasis and provided the foundation for biologic drug development in psoriasis and psoriatic arthritis. Throughout her career, she has taught dermatologists how to diagnose and manage psoriatic arthritis.

ABSTRACT: Patients with inflammatory bowel disease (IBD) are at higher risk of septic and thromboembolic complications after surgery. While these patients’ cases are often complicated from a surgical perspective, we now also manage them with a variety of immunosuppressive agents that can increase the risk of postsurgical complications. Whether to withhold or continue these medications in the perioperative period is the subject of ongoing debate in the IBD surgical community.

Pages